HA1/AP1 adaptor complex (clathrin assembly protein [AP]-1)

^[1]^[2]

Function

role in protein sorting in the trans-Golgi network (TGN) &/or endosomes
specifically recognizes or associates clathrin-coated vesicles within the trans-GOLGI
the AP complexes mediate both the recruitment of clathrin to membranes & the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules

heterotetramer composed
- AP1G1 (gamma-type subunit)
- AP1B1 (beta-type subunit)
- AP1M1 or AP1M2 (mu-type subunit)
- AP1S1, AP1S2 or AP1S3 (sigma-type subunit)

↑ Serafini T et al A coat subunit of Golgi-derived non-clathrin-coated vesicles with homology to the clathrin-coated vesicle coat protein beta-adaptin. Nature. 1991 Jan 17;349(6306):215-20. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1898984
↑ Morris SA, Mann A, Ungewickell E. Analysis of 100-180-kDa phosphoproteins in clathrin-coated vesicles from bovine brain. J Biol Chem. 1990 Feb 25;265(6):3354-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1968063