AP-1 complex subunit sigma-2; adapter-related protein complex 1 sigma-1B subunit; adaptor protein complex AP-1 sigma-1B subunit; sigma-adaptin 1B; sigma1B-adaptin; Golgi adaptor HA1/AP1 adaptin sigma-1B subunit; clathrin assembly protein complex 1 sigma-1B small chain; sigma 1B subunit of AP-1 clathrin (AP1S2)

Function

• one of 4 subunits of clathrin assembly protein complex 1 (AP-1) associated with GOLGI
• small or sigma subunit
• binds to MUC1

Structure

• belongs to the adaptor complexes small subunit family

Compartment

• Golgi, cytoplasmic vesicle membrane
• peripheral membrane, cytoplasmic side
• membrane, clathrin-coated pit
• component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex

Expression

widely expressed

Pathology

• defects in AP1S2 are the cause of X-linked mental retardation 59

More general terms

• sigma adaptin

Additional terms

• clathrin (triskelion)

Component of

• HA1/AP1 adaptor complex (clathrin assembly protein [AP]-1)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8905
• OMIM: https://mirror.omim.org/entry/300629
• OMIM: https://mirror.omim.org/entry/300630
• UniProt: http://www.uniprot.org/uniprot/P56377.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1174