NADH dehydrogenase; respiratory chain complex-I; NADH CoQ reductase;NADH-ubiquinone oxidoreductase

Function

• multienzyme complex 1 of mitochondrial electron transport

NADH + ubiquinone <--> NAD+ + ubiquinol

NADH + acceptor <--> NAD+ + reduced acceptor

Structure

• an estimated 45 subunits
• subunits encoded by mitochondrial (7-13) & nuclear (> 20) genes

Pathology

• defects in subunits associated with NADH dehydrogenase deficiency

More general terms

• cytochrome reductase
• dehydrogenase
• quinone reductase
• multienzyme complex
• electron transport enzyme

Additional terms

• 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
• electron transport
• NADH dehydrogenase deficiency (complex 1 mitochondrial respiratory chain deficiency)

Components

• NADH dehydrogenase [ubiquinone] 1 subunit C2, isoform 2; NDUFC2-KCTD14 readthrough transcript protein (NDUFC2-KCTD14)

Database

• OMIM: https://mirror.omim.org/entry/602137