1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
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Introduction
Neurotoxin origionally isolated from impure preparations of heroin
Adverse effects
- parkinsonism Mechansim of action:
- selective effects on substantia nigra dopaminergic neurons
- inhibits complex I (NADH-CoQ oxidoreductase) of the mitochondrial electron transport chain
More general terms
Additional terms
References
- ↑ Lang & Lazano NEJM 339:1044-53, 1998