beta' adaptin (adaptor-related protein complex 1, beta-1 subunit, clathrin adaptor complex AP1, beta subunit)

Function

• subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/ trans-Golgi network (TGN) &/or endosomes

Structure

• belongs to the adaptor complexes large subunit family

Compartment

• Golgi
• cytoplasmic vesicle,
• clathrin-coated vesicle membrane
• peripheral membrane, cytoplasmic side
• component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex

Alternative splicing

named isoforms=2

Expression

widely expressed

Pathology

• deletion of the AP1B1 gene may play a role in tumorigenesis of meningiomas

More general terms

• adaptin

Additional terms

• clathrin (triskelion)

Component of

• HA1/AP1 adaptor complex (clathrin assembly protein [AP]-1)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:162
• UniProt: http://www.uniprot.org/uniprot/Q10567.html
• OMIM: https://mirror.omim.org/entry/600157
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=162