CD63; granulophysin; tetraspanin-30; Tspan-30; melanoma-associated antigen ME491; platelet activation antigen Pltgp40; ocular melanoma-associated antigen OMA81H; lysosome-associated membrane glycoprotein-3; lamp-3; antigen AD1 (NKI/C3)

Function

• associated with early stages of melanoma tumor progression
• may play a role in growth regulation

Structure

belongs to the tetraspanin (TM4SF) family

Compartment

• cell membrane; multi-pass membrane protein
• lysosome membrane
• late endosome membrane
• found in Weibel-palade bodies of endothelial cells
• located in platelet dense granules

Expression

• activated platelets
• macrophages
• fibroblasts
• osteoclasts
• endothelium
• smooth muscle
• brain white matter
• peripheral nerve
• synovial cells (lining)

Pathology

• expressed in:
  • dysplastic nevi
  • radial growth phase, primary melanomas
• associated with early stages of melanoma progression

More general terms

• tetraspanin (transmembrane-4-superprotein)
• lysosome-associated membrane glycoprotein (LAMP)
• CD antigen
• melanoma associated antigen (MAGE)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=967
• OMIM: https://mirror.omim.org/entry/155740
• UniProt: http://www.uniprot.org/uniprot/P08962.html