hepatitis B virus (HBV)

^[1]^[2]^[3]

Epidemiology

HBV is infectious >= 1 month on a surface at room temperature^[2]

HBsAg (surface antigen)
- protein surface coat
- spills into the circulation in great excess
- earliest serum marker of hepatitis B (HBV) infection
- disappears from serum after resolution of HBV infection
- anti-HBsAg antibody is protective
HBcAg (viral core protein)
- IgM antibody to HBcAg (IgM anti-HBc)
  - follows appearance of HBsAg in serum
  - marker of acute hepatitis B infection
- IgG antibody to HBcAg (IgG anti-HBc)
  - indicates recovery from acute infection
HBeAg
- shares homology with HBcAg
- presence in serum
  - correlates with infectivity
  - identifies candidates for interferon treatment of chronic hepatitis B infection
viral DNA polymerase
viral double-stranded DNA genome

HBXAP facilitates transcription of hepatitis B virus (HBV) genes by the HBV pX transcription activator
apparently highjacks cellular gamma-2-adaptin (AP1G2) during viral maturation

↑ Medical Knowledge Self Assessment Program (MKSAP) 11, 2018. American College of Physicians, Philadelphia 1998, 2018.
↑ ^2.0 ^2.1 Veterans Administration, Mather CA
↑ ^3.0 ^3.1 ARUP Consult: Hepatitis B Virus - HBV The Physician's Guide to Laboratory Test Selection & Interpretation https://www.arupconsult.com/content/hepatitis-b-virus
Hepatitis B Virus Testing Algorithm https://arupconsult.com/algorithm/hepatitis-b-virus-testing-algorithm