hepatitis B virus X-associated protein; remodeling & spacing factor 1; Rsf-1; HBV pX-associated protein 8; p325 subunit of RSF chromatin-remodeling complex (RSF1 HBXAP XAP8)

Function

• required for assembly of regular nucleosome arrays by the RSF chromatin remodelling complex
• represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain
• phosphorylated upon DNA damage, probably by ATM or ATR
• interacts with SMARCA5 to form the RSF complex

Structure

• contains 1 DDT domain
• contains 1 PHD-type Zn+2 finger

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

ubiquitously expressed

Pathology

• mutations in gene associated with aggressive ovarian cancer
• binds the hepatitis B virus (HBV) pX/HBx protein
  • facilitates transcription of hepatitis B virus (HBV) genes by the HBV pX transcription activator
  • in case of infection by HBV, together with pX, represses TNF-alpha induced NF-kappa-B transcription activation

More general terms

• nuclear protein
• zinc finger protein
• phosphoprotein

Additional terms

• ovarian cancer

Component of

• RSF chromatin remodelling complex (remodeling & spacing factor)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51773
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51773
• OMIM: https://mirror.omim.org/entry/608522
• UniProt: http://www.uniprot.org/uniprot/Q96T23.html