SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5; sucrose nonfermenting protein 2 homolog; hSNF2H (SMARCA5, SNF2H, WCRF135)
Jump to navigation
Jump to search
Function
- helicase with intrinsic ATP-dependent nucleosome-remodeling activity
- complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails
- also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A
- probably plays a role in repression of RNA polymerase 1 dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter
- component of the WICH complex
- component of the nucleolar remodeling complex (NoRC)
- catalytic subunit of chromatin-remodeling complexes:
- CHRAC complex, RSF complex, ACF/WCRF complex, & WICH complex
- each complex contains subunits which may regulate the specificity or catalytic activity of SMARCA5
- ACF/WCRF complex contains BAZ1A
- CHRAC complex contains BAZ1A, CHRAC1, & POLE3
- RSF complex contains RSF1
- WICH complex contains BAZ1B/WSTF
- SMARCA5 is the catalytic subunit of the NoRC complex, which also contains BAZ2A/TIP5
- catalytic subunit of SMARCA5/cohesin/NuRD complexes
- interacts with MYO1C (putative)
Structure
- belongs to the SNF2/RAD54 helicase family, ISWI subfamily
- contains 1 helicase ATP-binding domain
- contains 1 helicase C-terminal domain
- contains 2 SANT domains
Compartment
Expression
ubiquitously expressed
Pathology
- overexpressed in CD34-positive erythrocyte progenitor cells in acute myeloid leukemia
- down-regulation correlates with hematologic remission following chemotherapy
More general terms
- SWI/SNF-related matrix-associated actin dependent regulator of chromatin subfamily A
- DEAD box ATP-dependent helicase
- phosphoprotein