bromodomain adjacent to zinc finger domain 2A (transcription termination factor I-interacting protein 5, TTF-I-interacting protein 5, Tip5, hWALp3, BAZ2A, KIAA0314, TIP5)

Function

• transcriptional regulation interacting with ISWI
• maintaining or altering the chromatin structure of the rDNA locus (putative)
• together with SMARCA5, forms a complex termed NoRC (nucleolar remodeling complex)

Structure

• belongs to the WAL family
• contains 4 A.T hook DNA-binding domains
• contains 1 bromo domain
• contains 1 DDT domain
• contains 1 MBD domain (methyl-CpG-binding domain 60 contains 1 PHD-type zinc finger

Compartment

• nucleus, nucleolus
• colocalizes with basal RNA polymerase 1 transcription factor UBF in the nucleolus

Alternative splicing

named isoforms=2

Expression

• expressed in most tissues, including heart, brain, placenta, lung, skeletal muscle, kidney, pancreas

More general terms

• zinc finger protein

Database

• OMIM: https://mirror.omim.org/entry/605682
• UniProt: http://www.uniprot.org/uniprot/Q9UIF9.html