nucleolar transcription factor 1; autoantigen NOR-90; upstream-binding factor 1; UBF-1 (UBTF, UBF, UBF1)
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Function
- required for transcriptional activator-dependent transcription from TATA-containing promoters[4]
- not required for rRNA transcription, but nonetheless DNA transcription is stimulated in the presence of UBF1[6]
- UBF1-stimulated RNA polymerase-1 activity is inhibited by Rb protein[6]
- recognizes the ribosomal RNA gene promoter & activates transcription mediated by RNA polymerase 1 through cooperative interactions with the species-specific transcription factor SL1
- binds specifically to the upstream control element
- phosphorylated & activated by PIK3CA (putative)
- binds to IRS1 & PIK3CA (putative)
Structure
- homodimer
- contains 6 HMG box DNA-binding domains
Compartment
Alternative splicing
named isoforms=2
Expression
- 50,000 molecules/cell
Pathology
- autoantibodies to UBF1 rarely present in patients with scleroderma
Laboratory
More general terms
Additional terms
References
- ↑ Bell et al Science 241:1192 1988
- ↑ Parisi MA, Clayton DA. Similarity of human mitochondrial transcription factor 1 to high mobility group proteins. Science. 1991 May 17;252(5008):965-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2035027
- ↑ Weis L, Reinberg D. Transcription by RNA polymerase II: initiator-directed formation of transcription-competent complexes. FASEB J. 1992 Nov;6(14):3300-9. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1426767
- ↑ 4.0 4.1 Chiang CM, Roeder RG. Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators. Science. 1995 Jan 27;267(5197):531-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7824954
- ↑ Dynlacht BD. Retinoblastoma protein. Pol I gets repressed. Nature. 1995 Mar 9;374(6518):114. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7877677
- ↑ 6.0 6.1 6.2 Cavanaugh AH, Hempel WM, Taylor LJ, Rogalsky V, Todorov G, Rothblum LI. Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product. Nature. 1995 Mar 9;374(6518):177-80. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7877691
- ↑ Clinical Diagnosis & Management by Laboratory Methods, 19th edition, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 1019