nucleolar remodeling complex (NoRC complex)

Function

• mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes & DNA methyltransferases, leading to heterochromatin formation & transcriptional silencing
• SMARCA5 is the catalytic subunit of NoRC
• the BAZ2A/TIP5 subunit of NoRC interacts with SMARCA5, DNMT1, DNMT3B & HDAC1, which allows NoRC to actively suppress rDNA transcription by a combination of nucleosome remodeling, histone deacetylation, & DNA methylation

Structure

• subunits: SMARCA5, BAZ2A/TIP5, DNMT1, DNMT3B & HDAC1

More general terms

• molecular complex