DNA (cytosine-5)-methyltransferase 1; Dnmt1; CXXC-type zinc finger protein 9; DNA methyltransferase HsaI; DNA MTase HsaI; M.HsaI; MCMT (DNMT1 AIM CXXC9 DNMT)

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Function

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine

Structure

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

Genetics

More general terms

Additional terms

References

  1. UniProt http://www.uniprot.org/uniprot/P26358.html
  2. Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/DNMT1ID40347ch19p13.html
  3. Fuks F et al DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nature Genetics 24:88, 2000 PMID: https://www.ncbi.nlm.nih.gov/pubmed/10615135
  4. Rhee I et al CpG methylation is maintained in human cancer cells lacking DNMT1. Nature 404:1003, 2000 PMID: https://www.ncbi.nlm.nih.gov/pubmed/10801130

Database