methyl-CpG-binding domain protein 3; methyl-CpG-binding protein MBD3 (MBD3)

Function

• does not bind DNA by itself
• recruits histone deacetylases & DNA methyltransferases
• acts as transcriptional repressor & plays a role in gene silencing
• heterodimer with MBD2
• part of the NuRD complex & the MeCP1 complex
• binds HDAC1, MTA2, DNMT1, p66-alpha & p66-beta

Structure

contains 1 MBD (methyl-CpG-binding) domain

Compartment

• nucleus
• nuclear, in discrete foci

Alternative splicing

named isoforms=2

More general terms

• methyl-CpG-binding protein (MECP, Me-CpG-BP)
• phosphoprotein

Additional terms

• DNA methylation (promoter methylation)

Component of

• nucleosome remodeling & histone deacetylation (NuRD) complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=53615
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:53615
• OMIM: https://mirror.omim.org/entry/603573
• UniProt: http://www.uniprot.org/uniprot/O95983.html