metastasis-associated protein MTA2; metastasis-associated 1-like 1; MTA1-L1 protein; p53 target protein in deacetylase complex (MTA2, MTA1L1, PID)

Function

• may be involved in the regulation of gene expression as repressor & activator
• repression might be related to covalent modification of histone proteins
• component of the nucleosome-remodeling & histone-deacetylase multiprotein complex (NuRD complex)
• interacts with HDAC7, p53/TP53, MINT & MBD3 (putative)

Structure

• contains 1 BAH domain
• contains 1 ELM2 domain
• contains 1 GATA-type Zn+2 finger
• contains 1 SANT domain

Compartment

nucleus (putative)

Expression

widely expressed

More general terms

• zinc finger protein
• nuclear protein
• phosphoprotein

Additional terms

• histone deacetylase
• metastasis

Component of

• nucleosome remodeling & histone deacetylation (NuRD) complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9219
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9219
• OMIM: https://mirror.omim.org/entry/603947
• UniProt: http://www.uniprot.org/uniprot/O94776.html