DNA methyltransferase 1-associated protein 1; DNMAP1; DNMT1-associated protein 1 (DMAP1, KIAA1425)

Function

• role in transcription repression & activation
• interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins
• can also repress transcription independently of histone deacetylase activity
• may specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription
• component of the NuA4 histone acetyltransferase complex (HAT complex)
• DMAP1 also forms a complex with DNMT1 & HDAC2
• throughout S phase it interacts directly with the N-terminus of DNMT1, which serves to recruit DMAP1 to replication foci
• DMAP1 interacts with ING1,
• component of the msin3A transcription repressor complex
• interacts directly with the transcriptional corepressor TSG101
• interacts with the pro-apoptotic protein DAXX

Structure

contains 1 SANT domain

Compartment

• nucleus
• targeted to replication foci throughout S phase by DNMT1

More general terms

• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55929
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55929
• OMIM: https://mirror.omim.org/entry/605077
• UniProt: http://www.uniprot.org/uniprot/Q9NPF5.html