inhibitor of growth protein 1; transforming growth factor beta-1 response element (ING1)

Function

• cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation
• implicated as a tumor suppressor gene
• interacts with H3K4me3 & to a lesser extent with H3K4me2
• interacts with TP53

Structure

• the PHD-type Zn+2 finger mediates binding to H3K4me3
• the polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdinsPs), including phosphatidylinositol-5-phosphate (Ptdins(5)P) (putative)
• belongs to the ING family
• contains 1 PHD-type Zn+2 finger

Compartment

nucleus (probable)

Alternative splicing

named isoforms=5

Expression

• isoform 2
  • expressed in all normal tissues & cells examined
  • expressed in all breast cancer & melanoma cell lines examined
• isoform 3
  • expressed in testis, liver, & kidney
  • weaklt expressed in colon & brain
  • not expressed in breast & cultured melanocytes
• isoform 4
  • highly expressed in testi
    • weakly expressed in brain
    • not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines

Pathology

• defects in ING1 are a cause of head & neck cancer

More general terms

• inhibitor of growth protein
• zinc finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3621
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3621
• OMIM: https://mirror.omim.org/entry/275355
• OMIM: https://mirror.omim.org/entry/601566
• UniProt: http://www.uniprot.org/uniprot/Q9UK53.html