translocator protein; peripheral-type benzodiazepine receptor; PBR; PKBS; mitochondrial benzodiazepine receptor (TSPO, BZRP, MBR)

Function

• distinct from allosteric benzodiazepine site on GABA-A receptor
• most likely to comprise binding domains for benzodiazepines & isoquinoline carboxamides
• promotes production of GABA-A receptors
• may play a role in the transport of porphyrins & heme
• role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells (putative)
• interacts with BZRAP1 (putative)
• may interact with STAR (putative)
• interacts with MOST-1

Structure

belongs to the TspO/BZRP family

Compartment

mitochondrial membrane

Pharmacology

• binds novel anxiolytic XBD173

More general terms

• transmembrane 5 protein
• receptor
• mitochondrial membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=706
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:706
• OMIM: https://mirror.omim.org/entry/109610
• UniProt: http://www.uniprot.org/uniprot/P30536.html