chromatin accessibility complex protein 1 (DNA polymerase epsilon 15 kD subunit, HuCHRAC15, CHRAC1, CHRAC15)

Function

• forms a complex with DNA polymerase epsilon subunit POLE3 & binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H & ACF1
• together with POLE3, ACF1 & ISWI/SNF2H proteins, forms the ISWI chromatin-remodeling complex, CHRAC

Compartment

nucleus (putative)

Expression

• expressed in all tissues tested, including, heart, brain, placenta, lung, liver, skeletal muscle, kidney & pancreas

More general terms

• protein subunit
• phosphoprotein

Component of

• DNA polymerase epsilon
• ISWI chromatin remodelling complex CHRAC

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5410
• OMIM: https://mirror.omim.org/entry/607268
• UniProt: http://www.uniprot.org/uniprot/Q9NRG0.html