DNA polymerase epsilon

Function

• role in DNA repair & in chromosomal DNA replication
• the yeast DNA polymerase epsilon is a G1/S checkpoint DNA repair polymerase
• elongation of primed DNA templates by DNA polymerase epsilon requires the action of the accessory proteins PCNA & replication factor C

Structure

• consists of four subunits: POLE1, POLE2, POLE3 & POLE4
• yeast DNA polymerase epsilon contains an N-terminal polymerase domain & a C-terminal checkpoint domain that senses DNA replication

More general terms

• DNA polymerase
• exodeoxyribonuclease
• multisubunit protein

Additional terms

• proliferating cell nuclear antigen (PCNA)