DNA polymerase epsilon catalytic subunit (subunit A, subunit 1, POLE, POLE1)

Function

• role in DNA repair & in chromosomal DNA replication
• interacts with RAD17 & TOPBP1
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• DNA polymerase activity domain resides in the N-terminal half of the protein
• the C-terminus is necessary for complexing subunits B & C
• C-terminus may also regulate catalytic activity
• belongs to the DNA polymerase type-B family

Compartment

nucleus

More general terms

• protein subunit
• zinc finger protein
• phosphoprotein

Component of

• DNA polymerase epsilon

Database

• UniProt: http://www.uniprot.org/uniprot/Q07864.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5426
• OMIM: https://mirror.omim.org/entry/174762