replication factor-C

Function

• elongation of primed DNA templates by DNA polymerase delta & DNA polymerase epsilon requires the action of the accessory proteins PCNA & replication factor-C (activator 1)
• complex containing RFC1 forms a complex with PCNA in the presence of ATP stimulating ATPase activity
• complex containing RAD17 does not interact with PCNA

Subunits

• heteropentamer of subunits: replication factor C subunit 1 (RFC1) replication factor C subunit 2 (RFC2) replication factor C subunit 3 (RFC3) replication factor C subunit 4 (RFC4) replication factor C subunit 5 (RFC5)
• RFC2, RFC2, RFC4, & RFC5 may complex with either RFC1 or RAD17
• RFC2, RFC2, RFC4, & RFC5 may complex with CTF18, CTF8, & DCC1 in the CTF18-RFC complex

More general terms

• adenosine triphosphatase (ATPase)
• DNA-binding protein
• nuclear protein
• multisubunit protein

Additional terms

• CTF18-replication factor C
• proliferating cell nuclear antigen (PCNA)

Component of

• BRCA1-associated genome surveillance complex (BASC)