chromosome transmission fidelity protein 18 homolog (hCTF18, CHTF18, CTF18)

Function

• chromosome cohesion factor involved in sister chromatid cohesion & fidelity of chromosome transmission
• component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC)
• CTF18 then interacts directly with CTF8, which in turn interacts with DCC1
• CTF18 interacts with SMC1A & RAD21

Structure

• belongs to the activator 1 small subunits family CTF18 subfamily

Compartment

• nucleus
• associates with chromatin during S phase

Alternative splicing

named isoforms=3

More general terms

• nuclear protein
• phosphoprotein

Component of

• CTF18-replication factor C
• chromosome transmission fidelity protein 18 homolog (hCTF18, CHTF18, CTF18)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6392
• UniProt: http://www.uniprot.org/uniprot/Q8WVB6.html