chromosome transmission fidelity protein 8 homolog; hCTF8 (CHTF8, CTF8)

Function

• chromosome cohesion factor involved in sister chromatid cohesion & fidelity of chromosome transmission
• component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC complex)
• CTF8 exists as a dimer with DCC1

Structure

belongs to the CTF8 family

Compartment

• nucleus
• associates with chromatin during S phase

Alternative splicing

named isoforms=2

Expression

• ubiquitously expressed
• abundant expression in kidney, skeletal muscle, testis, liver, ovary, & heart
• moderate expression in prostate

Pathology

• expression is significantly reduced in renal cancer & prostate cancer
• no differential expression in breast cancer cells, between lobular carcinoma & normal lobules

More general terms

• nuclear protein

More specific terms

• chromosome transmission fidelity protein 8 homolog isoform 2; decreased expression in renal & prostate cancer protein (CHTF8, DERPC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54921
• OMIM: https://mirror.omim.org/entry/613202
• UniProt: http://www.uniprot.org/uniprot/P0CG13.html