chromosome transmission fidelity protein 8 homolog isoform 2; decreased expression in renal & prostate cancer protein (CHTF8, DERPC)

Function

• may be tumor suppressor
• inhibits prostate tumor cell growth, when overexpressed

Structure

belongs to the DERPC family

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• ubiquitously expressed
• abundant expression in kidney, skeletal muscle, testis, liver, ovary, & heart
• moderate expression in prostate

Pathology

• expression is significantly reduced in renal cancer & prostate cancer
• no differential expression in breast cancer cells, between lobular carcinoma of the breast & normal lobules

Genetics

• found in a common chromosomal region of deletion in breast cancer

More general terms

• chromosome transmission fidelity protein 8 homolog

Database

• OMIM: https://mirror.omim.org/entry/613202
• UniProt: http://www.uniprot.org/uniprot/P0CG12.html