CTF18-replication factor C

Function

• binds to single-stranded & primed DNAs
• weak ATPase activity stimulated by PCNA
• catalyzes the ATP-dependent loading of PCNA onto primed & gapped DNA
• interacts with & stimulates DNA polymerase POLH
• interacts with & stimulates POLN, which is suggestive of a protein network that coordinates DNA repair, recombination & chromosome cohesion reactions with replication fork progression
• does not interact with the Rad9/Rad1/Hus1 complex

Structure

• subunits: CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 & RFC5

More general terms

• molecular complex

Additional terms

• replication factor-C