replication factor C subunit 2 (replication factor C 40 kD subunit, RF-C 40 kD subunit, RFC40, activator 1 40 kD subunit, A1 40 kD subunit, RFC2)

Function

• one of 5 subunits of replication factor C
• binds ATP
• RFC2 interacts with PRKAR1A; interaction may be involved in cell survival

Structure

belongs to the activator 1 small subunits family

Compartment

nucleus (probable)

Alternative splicing

named isoforms=2

Pathology

• haploinsufficiency of RFC2 may be the cause of certain cardiovascular & musculo-skeletal abnormalities observed in Williams-Beuren syndrome

More general terms

• protein subunit

Component of

• replication factor-C
• CTF18-replication factor C

Database

• OMIM: https://mirror.omim.org/entry/194050
• OMIM: https://mirror.omim.org/entry/600404
• UniProt: http://www.uniprot.org/uniprot/P35250.html