cell cycle checkpoint protein RAD1; hRAD1; DNA repair exonuclease rad1 homolog; Rad1-like DNA damage checkpoint protein (RAD1, REC1)

Function

• component of the 9-1-1 complex
• isoform 1 possesses 3'->5' double stranded DNA exonuclease activity to yield nucleoside 5'-phosphates
• RAD1 interacts with POLB, FEN1, HUS1, HUS1B, RAD9A, RAD9B
• interacts with DNAJC7

Structure

belongs to the rad1 family

Compartment

nucleus

Alternative splicing

• named isoforms=3
• at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Expression

• expressed in testis, uterus, bladder, spleen, ovaries, lung, brain, muscle

More general terms

• exodeoxyribonuclease
• nuclear protein

Component of

• 9-1-1 cell-cycle checkpoint response complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5810
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5810
• OMIM: https://mirror.omim.org/entry/603153
• UniProt: http://www.uniprot.org/uniprot/O60671.html