DnaJ homolog subfamily C member 7; tetratricopeptide repeat protein 2; TPR repeat protein 2 (DNAJC7, TPR2, TTC2)

Function

• acts as co-chaperone regulating the molecular chaperones HSP70 & HSP90 in folding of steroid receptors, such as the glucocorticoid receptor & the progesterone receptor
• recycling chaperone by facilitating return of chaperone substrates to early stages of chaperoning if further folding is required (putative)
• in vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes
• recruits CXADR to the cytoplasm
• associates with complexes containing chaperones HSP70 & HSP90
• interacts with the GAP domain of NF1
• interacts with HSP90AA1
• interacts with HSPA1A/B; the interaction is enhanced by ATP
• interacts with HSP90AB1
• interacts with PGR
• interacts with RAD9A; the interaction is interrupted by UV & heat shock treatments
• interacts with HUS1 & RAD1
• interacts with CXADR
• probably part of a complex containing CXADR, HSP90AA1 & DNAJC7
• interacts with HSPA8

Structure

• contains 1 J domain
• contains 9 TPR repeats

Compartment

• cytoplasm, nucleus, cytoskeleton
• colocalizes with CXADR to microtubules

More general terms

• DNAJ homolog subfamily C
• tetratricopeptide repeat protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7266
• OMIM: https://mirror.omim.org/entry/601964
• UniProt: http://www.uniprot.org/uniprot/Q99615.html