cell cycle checkpoint control protein RAD9A; hRAD9; DNA repair exonuclease rad9 homolog A (RAD9A)

Function

• component of the 9-1-1 cell-cycle checkpoint response complex
• 3'->5' double stranded DNA exonuclease activity
  • exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates
• constitutively phosphorylated on Ser & Thr in absence of DNA damage
• hyperphosphorylated by PRKCD & ABL1 upon DNA damage
• phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex
• interacts with BCL2L1, FEN1, PRKCD, RAD9B, HUS1, RAD1, ABL1, RPA1, RPA2
• interacts with DNAJC7 & RHNO1

Compartment

nucleus

More general terms

• exodeoxyribonuclease
• phosphoprotein

Component of

• 9-1-1 cell-cycle checkpoint response complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5883
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5883
• OMIM: https://mirror.omim.org/entry/603761
• UniProt: http://www.uniprot.org/uniprot/Q99638.html