Progesterone receptor; PR; nuclear receptor subfamily 3 group C member 3 (PGR, NR3C3)
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Function
- nuclear hormone receptor
- interacts with CUEDC2, SMARD1 & with UNC45A
- cytoplasmic anchoring &/or assembly associated with heat shock proteins hsp70 & hsp90 & immunophilin p59FKBP
Structure
- composed of three domains:
- modulating N-terminal domain
- DNA-binding domain
- C-terminal steroid-binding domain
- belongs to the nuclear hormone receptor family, NR3 subfamily
- contains 1 nuclear receptor DNA-binding domain
Compartment
Alternative splicing
named isoforms=2
More general terms
Additional terms
- FK506-binding protein 4 (52 kD FK506 binding protein, hsp-binding immunophilin, FKBP59, FKBP4)
- heat shock protein [hsp] 70, HSP70A or HSP-A
- heat shock protein [hsp]-90
- hormone (estrogen) receptor status panel
- membrane progestin receptor gamma (mPR gamma, progestin & adipoQ receptor family member V, PAQR5, MPRG)
- membrane-associated progesterone receptor component 1; mPR (PGRMC1, HPR66, PGRMC)
- membrane-associated progesterone receptor component 2; progesterone membrane-binding protein; steroid receptor protein DG6 (PGRMC2, DG6, PMBP)
- progesterone (Progestasert, Prometrium, Pro-Gest, Prochieve)
References
- ↑ Alberts et al Molecular Biology of the Cell, 2nd ed. 1989, pg 704
- ↑ Wang KK et al Calmodulin-binding proteins as calpain substrates. Biochem J 262:693 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2556106
- ↑ Hoffman EC, Reyes H, Chu FF, Sander F, Conley LH, Brooks BA, Hankinson O. Cloning of a factor required for activity of the Ah (dioxin) receptor. Science. 1991 May 17;252(5008):954-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1852076
- ↑ Progesterone receptor entry http://en.wikipedia.org/wiki/Progesterone_receptor
- ↑ UniProt http://www.uniprot.org/uniprot/P06401.html