membrane-associated progesterone receptor component 1; mPR (PGRMC1, HPR66, PGRMC)

Function

• receptor for progesterone (putative)

Structure

• the cytochrome b5 heme-binding domain lacks the conserved iron-binding His at positions 107 & 131
• belongs to the cytochrome b5 family, MAPR subfamily
• contains 1 cytochrome b5 heme-binding domain

Compartment

• microsome membrane
• single-pass membrane protein (putative)
• endoplasmic reticulum membrane

Expression

• widely expressed
• highest expression in liver & kidney

More general terms

• membrane protein
• phosphoprotein

Additional terms

• Progesterone receptor; PR; nuclear receptor subfamily 3 group C member 3 (PGR, NR3C3)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10857
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10857
• OMIM: https://mirror.omim.org/entry/300435
• UniProt: http://www.uniprot.org/uniprot/O00264.html