cytochrome b5 (CYB5A, CYB5)

Function

• membrane bound hemoprotein
• electron carrier for several membrane bound oxygenases

Structure

• belongs to the cytochrome b5 family
• contains 1 cytochrome b5 heme-binding domain

Compartment

• isoform 1: endoplasmic reticulum membrane, cytoplasmic side
• isoform 2: cytoplasm

Alternative splicing

named isoforms=2

Pathology

• defects in CYB5A are the cause of hereditary methemoglobinemia type 4 [MIM:250790]

More general terms

• cytochrome
• membrane protein

More specific terms

• cytochrome b5 type B; cytochrome b5 outer mitochondrial membrane isoform (CYB5B, CYB5M, OMB5)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1528
• OMIM: https://mirror.omim.org/entry/250790
• UniProt: http://www.uniprot.org/uniprot/P00167.html