FK506-binding protein 4 (52 kD FK506 binding protein, hsp-binding immunophilin, FKBP59, FKBP4)
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Function
- component of unactivated mammalian steroid receptor complex together with heat shock proteins HSP70 & HSP90
- may have a rotamase activity
- may play a role in the intracellular trafficking of hetero- oligomeric forms of steroid hormone receptors
- interacts with NR3C1 & dynein (putative)
- associates with HSP90 & HSP70 in unactivated steroid hormone receptor complexes
- interacts with peroxisomal phytanoyl-CoA alpha-hydroxylase (PHYH)
- phosphorylation by CK2 results in loss of HSP90 binding activity (putative)
- phosphorylated upon DNA damage, probably by ATM or ATR
peptidylproline (omega=180) <--> peptidylproline (omega=0)
Structure
- contains 2 PPIase FKBP-type domains
- contains 3 TPR repeats
Compartment
Expression
widely expressed
More general terms
References
- ↑ Ku Tai et al Science 256:1315 1992
- ↑ Martinus RD et al Role of chaperones in the biogenesis and maintenance of the mitochondrion. FASEB J. 1995 Mar;9(5):371-8. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7896006
- ↑ UniProt http://www.uniprot.org/uniprot/Q02790.html