heat shock 70 kD protein 1A; heat shock 70 kD protein 1; HSP70-1; HSP70.1 (HSPA1A, HSPA1, HSX70, HSP1A)

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Function

in cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation & mediate folding of newly translated polypeptides in the cytosol as well as within organelles
Hsp70s precognize nonnative conformations of other proteins
they bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation & membrane translocation, or following stress-induced damage
in the case of rotavirus A infection, HSPA1A serves as a post- attachment receptor for the virus to facilitate entry into the cell
essential for STUB1-mediated ubiquitination & degradation of FOXP3 in regulatory T-cells (treg) during inflammation
component of the catsper complex
identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs
interacts with CHCHD3, DNAJC7, IRAK1BP1, PPP5C & TSC2
interacts with TERT
- interaction occurs in the absence of the RNA component, TERC, & dissociates once the TERT complex has formed
interacts with TRIM5 (via B30.2/SPRY domain)
interacts with METTL21A
interacts with DNAAF2 (putative)
interacts with PARK2
interacts with FOXP3
interacts with NOD2
- interaction enhances NOD2 stability
interacts with DNAJC9 (via J domain)
interacts with ATF5
- interaction protects ATF5 from degradation via proteasome-dependent & caspase-dependent processes

induced by heat shock