activating transcription factor-5; cyclic AMP-dependent transcription factor ATF-5; transcription factor ATFx (ATF5, ATFX)

Function

• transcriptional activator which binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral & cellular promoters & blocks the differentiation of neuroprogenitor cells into neurons
• its transcriptional activity is enhanced by CCND3 & slightly inhibited by CDK4
• binds DNA as a dimer
• interacts with PTP4A1/PRL-1
• interacts with CCND3, but not with CCND1 or CCND2

Structure

• belongs to the bZIP family
• contains 1 bZIP domain

Compartment

cytoplasm, nucleus

More general terms

• activating transcription factor

Database

• UniProt: http://www.uniprot.org/uniprot/Q9Y2D1.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2280
• OMIM: https://mirror.omim.org/entry/606398
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22809