protein tyrosine phosphatase type IVA 1; PTP(CAAXI); protein-tyrosine phosphatase 4a1; protein-tyrosine phosphatase of regenerating liver 1; PRL-1 (PTP4A1 PRL1 PTPCAAX1)

Function

• stimulates progression from G1 into S phase during mitosis
• development and maintenance of differentiating epithelial tissues
• promotes tumor growth

Inhibition:

• sodium orthovanadate, pentamidine

Structure

farnesylated

Compartment

• plasma membrane, early endosome, endoplasmic reticulum, cytoplasm, mitotic spindle

Expression

• expressed in bone marrow, lymph nodes, T-cells, spleen, thymus, tonsil, fetal liver

Pathology

overexpressed in tumor cell lines

More general terms

• protein tyrosine phosphatase type IVA

Database

• OMIM: https://mirror.omim.org/entry/601585
• UniProt: http://www.uniprot.org/uniprot/Q93096.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7803