tripartite motif-containing protein 5; RING finger protein 88 (TRIM5 RNF88)

Function

• isoform alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection
• targets retroviral capsid soon after entry into the cell, & prevents reverse transcription of the virus RNA genome
• isoform alpha trimers may make multiple contacts with the
• hexameric lattice of CA proteins which constitute the surface of retrovirion core, & somehow inactivate the virus
• restricts infection by N-MLV, but not HIV-1
• may have E3 ubiquitin-protein ligase activity
• protein modification; protein ubiquitination
• ubiquitinates itself in vitro (RING finger & UBE2D2-dependent)
• isoform alpha forms homotrimers, & may interact with retroviral CA protein
• isoform delta interacts with BTBD1 & BTBD2

Structure

• the RING-type Zn+2 finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (putative)
• belongs to the TRIM/RBCC family
• contains 1 B box-type Zn+2 finger
• contains 1 B30.2/SPRY domain
• contains 1 RING-type Zn+2 finger

Compartment

• cytoplasm, P-body
• cytoplasmic bodies

Alternative splicing

• named isoforms=5
• alpha, beta, gamma, delta, epsilon

More general terms

• tripartite motif-containing protein (trim protein)
• phosphoprotein

More specific terms

• tripartite motif-containing protein 5-alpha (trim5-alpha)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=85363
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:85363
• OMIM: https://mirror.omim.org/entry/608487
• UniProt: http://www.uniprot.org/uniprot/Q9C035.html