BTB/POZ domain-containing protein 1; hepatitis C virus NS5A-transactivated protein 8; HCV NS5A-transactivated protein 8 (BTBD1 C15orf1 NS5ATP8)

Function

• probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination & subsequent proteasomal degradation of target proteins
• protein modification; protein ubiquitination
• interacts with topoisomerase 1 & with TRIM5 isoform delta
• interacts with CUL3

Structure

contains 1 BTB/POZ domain

Compartment

cytoplasm, P-body. Note: cytoplasmic bodies

Expression

• ubiquitous; higher levels in heart & skeletal muscle

More general terms

• BTB/POZ domain containing protein

Additional terms

• hepatitis C virus

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=53339
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:53339
• OMIM: https://mirror.omim.org/entry/608530
• UniProt: http://www.uniprot.org/uniprot/Q9H0C5.html