interleukin-1 receptor-associated kinase 1-binding protein 1 (IRAK1BP1)

Function

• component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation & is required for cell survival
• acts by enhancing RELA transcriptional activity
• interacts with IRAK1 & RELA
• interacts with HSPA8 & HSPA1 (putative)
• phosphorylation at Ser-56 &/or Ser-62 is required for full activity
• phosphorylated on at least one of Ser-235, Thr-237, Ser-242 & Thr-247 upon TNF-alpha activation, which favors nuclear translocation (putative)

Structure

• intrinsically disordered region interacts with HSPA1 & HSPA8 (putative)
• belongs to the IRAK1BP1 family

Compartment

cytoplasm, nucleus

More general terms

• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=134728
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:134728
• UniProt: http://www.uniprot.org/uniprot/Q5VVH5.html