interleukin-1 receptor associated kinase 1 (IRAK1)

Function

• binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation & mRNA stabilization
• isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the IL-1
• isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling
• once phosphorylated, IRAK1 recruits the adapter protein PELI1
• IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1
• interacts with IL1RL1
• interacts with IRAK1BP1
• autophosphorylation or phosphorylation by IRAK4 following recruitment to the IL-1RI is linked to ubiquitination & degradation of isoform 1

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, Pelle subfamily
• contains 1 protein kinase domain

Alternative splicing

named isoforms=3

Expression

• isoform 1 & isoform 2 are ubiquitously expressed in all tissues examined
• isoform 1 is more strongly expressed than isoform 2

More general terms

• interleukin-1 receptor associated kinase (IRAK)

Database

• UniProt: http://www.uniprot.org/uniprot/P51617.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3654
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3654
• OMIM: https://mirror.omim.org/entry/300283