E3 ubiquitin-protein ligase pellino homolog 1; pellino-1; pellino-related intracellular-signaling molecule (PELI1, PRISM)

Function

• E3 ubiquitin ligase
• catalyzes covalent attachment of ubiquitin moieties onto substrate proteins
• role in TLR & IL-1 signaling pathways via interaction with the complex containing IRAK kinases & TRAF6
• mediates Lys-63-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation
• protein modification; protein ubiquitination
• phosphorylated by IRAK1 & IRAK4 enhancing its E3 ligase activity
• sumoylated
• found in a complex containing TRAF6, IRAK1 & IRAK4
• interacts with MAP3K7

Structure

belongs to the pellino family

More general terms

• pellino protein homolog

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57162
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57162
• UniProt: http://www.uniprot.org/uniprot/Q96FA3.html