interleukin-1 receptor-like 1; protein ST2; growth stimulation expressed gene 2 protein (IL1RL1, DER4, ST2, T1)

Function

• receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, & TRAF6, followed by phosphorylation of MAPK3/ERK1 &/or MAPK1/ERK2, MAPK14, & MAPK8
• possibly involved in helper T-cell function
• interacts with MYD88, IRAK1, IRAK4, & TRAF6

Structure

• belongs to the interleukin-1 receptor family
• contains 3 Ig-like C2-type domains
• contains 1 TIR domain

Compartment

• isoform C: cell membrane
  • single-pass type 1 membrane protein
• isoform B: secreted

Alternative splicing

• named isoforms=3; ST2L, ST2S, ST2V
• at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Expression

• highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon & small intestine
• isoform A is prevalently expressed in the lung, testis, placenta, stomach & colon
• isoform B is more abundant in the brain, kidney & the liver
• isoform C is not detected in brain, heart, liver, kidney & skeletal muscle

Laboratory

• growth stimulation expressed gene 2 analysis

More general terms

• secreted protein
• glycoprotein
• cell surface receptor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9173
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9173
• OMIM: https://mirror.omim.org/entry/601203
• UniProt: http://www.uniprot.org/uniprot/Q01638.html