phosphoprotein phosphatase-5 catalytic subunit (protein phosphatase T, PP-T, PPT, PPP5C, PPP5)

Function

• may play a role in the regulation of RNA biogenesis &/or mitosis
• in vitro, dephosphorylates Ser of skeletal muscle phosphorylase & histone H1
• interacts with CDC16 & CDC27

phosphoprotein + H2O <--> a protein + phosphate

Cofactor:

• binds 1 iron ion per subunit (putative)
• binds 1 Mn+2 per subunit (putative)

Structure

• belongs to the PPP phosphatase family, PP-5 (PP-T) subfamily
• contains 3 TPR repeats

Compartment

• nucleus, cytoplasm
• predominantly nuclear, but also present in the cytoplasm

Expression

ubiquitous

More general terms

• serine/threonine phosphatase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5536
• OMIM: https://mirror.omim.org/entry/600658
• UniProt: http://www.uniprot.org/uniprot/P53041.html