anaphase promoting complex subunit 6 (cell division cycle protein 16 homolog, CDC16, CDC16Hs, APC6, cyclosome subunit 6)

Function

• component of the anaphase promoting complex/cyclosome (APC/C)
• interacts with PPP5C & CDC20
• phosphorylation on Ser-560 occurs specifically during mitosis

Structure

• belongs to the APC6/CDC16 family
• contains 7 TPR repeats

Compartment

• centrosome
• colocalizes with CDC27 to the centrosome at all stages of the cell cycle & to the mitotic spindle

Alternative splicing

named isoforms=3

More general terms

• protein subunit
• phosphoprotein

Component of

• anaphase promoting complex (APC, cyclosome)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8881
• OMIM: https://mirror.omim.org/entry/603461
• UniProt: http://www.uniprot.org/uniprot/Q13042.html