BRCA1-associated genome surveillance complex (BASC)
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Function
- role as a sensor of abnormal DNA structures &/or as a regulator of post-replication repair processes (putative)
Structure
- large molecular complex which includes tumor suppressors & DNA repair proteins
- subunits: BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 & the RAD50-MRE11-NBS1 complex
More general terms
References
- ↑ Wang Y et al. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes & Development 14:927-39, 2000 PMID: https://www.ncbi.nlm.nih.gov/pubmed/10783165