double-strand break repair protein MRE11A; meiotic recombination 11 homolog A; MRE11 homolog A; meiotic recombination 11 homolog 1; MRE11 homolog 1 (MRE11A, HNGS1, MRE11)

Function

• component of the MRN complex, thus role in DND double-strand break repair
• nuclease activity
• phosphorylated upon DNA damage, probably by ATM or ATR
• component of the BASC complex
• interacts with DCLRE1C/Artemis

Cofactor: Mn+2 (putative)

Structure

belongs to the MRE11/RAD32 family

Compartment

• nucleus (putative)
• localizes to discrete nuclear foci after treatment with genotoxic agents

Alternative splicing

named isoforms=2

Pathology

• defects in MRE11A are a cause of ataxia telangiectasia-like disorder
• defects in MRE11A may be a cause of breast cancer

Notes

• in case of infection by adenovirus E4, the MRN complex is inactivated & degraded by viral oncoproteins

More general terms

• hydrolase
• nuclear protein
• phosphoprotein

Component of

• BRCA1-associated genome surveillance complex (BASC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4361
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4361
• OMIM: https://mirror.omim.org/entry/600814
• OMIM: https://mirror.omim.org/entry/604391
• UniProt: http://www.uniprot.org/uniprot/P49959.html