MRN complex

Function

• double strand break repair complex
• cellular response to DNA damage
• maintenance of chromosome integrity
• DNA double-strand break repair
• DNA recombination
• maintenance of telomere integrity
• cell cycle checkpoint control
• meiosis
• single-strand endonuclease activity (MRE11A)
• double-strand-specific 3'-5' exonuclease activity (MRE11A)
• DNA-binding, holding ends in proximity (RAD50)
• nibrin modulates DNA damage signal sensing recruits ATM, ATR, DNA-PKcs to the DNA damage sites
• interacts with Artemis protein

Structure

• consists of at least:
  • MRE11A (2)
  • RAD50 (2)
  • Nibrin

Pathology

• see individual subnits (MRE11A, RAD50, Nibrin)
• complex is inactivated by infection with adenovirus E4 & degraded by viral oncoproteins

More general terms

• molecular complex