replication factor C subunit 1 (replication factor C p140, replication factor C large subunit, RF-C 140 kD subunit, activator 1 140 kD subunit, activator 1 large subunit, A1 140 kD subunit, DNA-binding protein PO-GA, RFC1, RFC140)

Function

• component of replication factor C
• RFC1 subunit binds to the primer-template junction
• binds the PO-B transcription element as well as other GA rich DNA sequences
• may play a role in DNA transcription regulation
• may play a role in DNA replication
• may play a role in DNA repair
• can bind single-stranded DNA or double-stranded DNA
• interacts with C-terminus of PCNA
• 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication &/or repair
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the activator 1 140 kD subunit family
• contains 1 BRCT domain

Compartment

nucleus

Alternative splicing

named isoforms=2 Alternative use of an acceptor site

Expression

• wide tissue distribution
• undetectable in placental tissue

More general terms

• protein subunit
• DNA-binding protein
• phosphoprotein
• zinc finger protein

Component of

• replication factor-C

Database

• UniProt: http://www.uniprot.org/uniprot/P35251.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5981
• OMIM: https://mirror.omim.org/entry/102579