bromodomain adjacent to zinc finger domain protein 1A (ATP-utilizing chromatin assembly & remodeling factor 1, hACF1, ATP-dependent chromatin remodelling protein, Williams syndrome transcription factor-related chromatin-remodeling factor 180, WCRF180, hWALp1, CHRAC subunit ACF1, BAZ1A, ACF1, HSPC317)

Function

• role in transcriptional regulation (putative)
• role in formation or maintenance of heterochromatin & developmental control
• component of ISWI chromatin remodelling complex CHRAC
• may target the CHRAC complex to heterochromatin
• stimulated by double-stranded DNA & nucleosomal DNA

Structure

• belongs to the WAL family
• contains 1 bromo domain
  • contains 1 DDT domain
  • contains 1 PHD-type zinc finger
  • contains 1 WAC domain

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• highly expressed in testis
• low or undetectable levels in other tissues

More general terms

• zinc finger protein

Component of

• ISWI chromatin remodelling complex CHRAC

Database

• OMIM: https://mirror.omim.org/entry/605680
• UniProt: http://www.uniprot.org/uniprot/Q9NRL2.html